Research & Development

There's been a lot of interest in turning less than appealing concentrates into a quality product. Standardizing a method to produce a consistent product is important for all manufactures.

Most Manufacturers use the following. This method is not recommend but is for information & educational purposes only:

The basic work flow prior to distillation is very important. There are two steps that must be completed prior to short path; winterization and decarboxylation.


Dissolve the extract in 190-200 proof ethanol at a 10:1 to 15:1 ratio depending on particulate load. Chill to at least -40c but ideally -80c for 24 hrs. Filter in a buchner funnel using filters on top of 2um fast flow filter paper. Distill alcohol in a still or rotovap.

Quick winterization:

Follow as above, except place dry ice directly into the ethanol solution and maintain for 2 hrs at -80C then filter immediately. Decarboxylation: Heat oil to 121c on a heated stir plate until all of the tiny bubbles are gone. If you get impatient and remove too early you'll likely have issues during the following steps.

Short Path distillation equipment:

A simple boiling flask with Vigreux condenser can be used to produce distillate. This is the most economical option but, also has the lowest yields.

After this the next step up in production is the wiped film evaporation.


There are 3 distinct fractions in this procedure; 1) the light volatile's that have boiling points below or slightly overlapping 2) the Cannabinoid's and 3) non volatile's. Dual fraction systems, those that separate one fraction at a time, temperature is raised gradually to remove the volatile fractions in order of their respective boiling points. Generally the lowers are removed below 185-195 ˚C depending on level of vacuum and film thickness. The Cannabinoids are separated next up to 260 ˚C in some devices and the black non-volatile fraction is discarded. Three fraction systems separate all three fractions in a single distillation step. Accomplishing this feat of engineering requires close attention to thermodynamics and residence times to separate the volatile's from non-volatile's in continuous operation.

What Advanced Synthesis Can Provide

The biggest issue at this step in the industry is pesticide, fungus, solvent and bacteria removal . Color removal is another issue when determining where the final material is going to be used. Bringing quality product to market is the purpose of all distributers and certain retailers have very strict levels for any impurities down to (PPB) Parts Per Billion in some states. Due to the nature of the cannabinoid product, this process can prove difficult for engineers. Advanced Synthesis has many years of experience working with organic compounds and is able to adapt procedures to bring pesticide, fungus, solvent and bacteria levels down to needed levels.

Why send product out to another company to do this process when you can do the process within your own company and save on logistics issues, time and paying another company to process your own material?

Advanced Synthesis can provide manufacturers not only with the equipment needed to perform these removal processes in-house but can also provide state of the art, time tested, organic compound procedures to produce static and dependable results for every batch of material. In addition Advanced Synthesis can provide procedures to increase recovery of material, help with color removal, and streamline existing procedures to obtain a faster turn around time in product processing. Contact Us today and find out what Advanced Synthesis can do for you.